Yet another fatal disease being solved by science

Categories: Med & Neuro
Published on: August 11, 2011

Gene therapy – another rapidly growing field of medicine (where genes are used to alter human cells properties) solves CLL, also known as chronic lymphocytic leukemia. The next in line are Ovarian cancer and Brain cancer.

The so called  CART19-cell infusion cured 3 different men in a matter of months after battling cancer for decades. Now it is obvious a very small sample size and it is correct to cautiosly wait the long-term results, BUT it is inevitable that this sort of approach would bring desired results.

A round of deserved applause to Michael Kalos, Bruce L. Levine, David L. Porter, Sharyn Katz, Stephan A. Grupp, Adam Bagg and Carl H. June (team leader).

Some early results could be seen on the graphics below:

 

 

Patient
(UPN)
Tissue Time
point
Amount of DNA
in PCR (ng)
Cell equivalents Total productive
sequence reads
Total productive
unique B cell
clonotypes
CLL IGH@
CDR3
clone reads
Clone frequency
(% productives)
01 PB Preinfusion 1000 158,730 184,786 24 184,256 99.713
01 PB Day −1 1000 158,730 408,579 48 407,592 99.758
01 PB Day +28 1000 158,730 0 0 0 0.000
01 PB Day +176 500 79,365 285,305 7,362 0 0.000
01 BM Day +28 1000 158,730 0 0 0 0.000
01 BM Day +176 1000 158,730 202,535 4,451 0 0.000
03 PB Preinfusion 2000 317,460 22,074,912 58,234 19,948,508 90.367
03 PB Day −1 386 61,270 1,385,340 4,544 1,231,018 88.860
03 PB Day +31 1000 158,730 0 0 0 0.000
03 PB Day +176 2000 317,460 0 0 0 0.000
03 BM Day +31 1750 277,778 0 0 0 0.000
03 BM Day +176 1000 158,730 0 0 0 0.000

 

See the sight of a cancer cells overrun by gene modified T-cells (although it looks like ice-cream scoops – I never liked chocolate ice cream):

 

There is a quick explanatory article of the experiments here: http://health.yahoo.net/news/s/ap/us_med_gene_therapy_leukemia

 

 

Be sure to read the research articles at:

http://www.nejm.org/doi/full/10.1056/NEJMoa1103849#t=articleTop

http://stm.sciencemag.org/content/3/95/95ra73.full

UPDATE: A good example of how hard is trying to solve a known problem by known method and how the known problem requires new way of thinking is the comparison between the gene therapy treatment and the treatment by a modified designer drug, which is very problematic to say the least. (For the latter se this article: http://uk.health.lifestyle.yahoo.net/modified-ecstasy-could-be-used-to-treat-cancer.htm )

 

 

 

 

Leave a Reply

Welcome , today is Wednesday, June 28, 2017